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Proses deteksi ini dimulai ketika sistem kekebalan mengenali epitop pada antigen. Epitop adalah subregion kecil pada antigen yang mensimulasikan pengenalan kekebalan.Upaya awal ini telah menyebabkan kebanyakan vaksin yang tersedia saat ini. Meskipun upaya ini berhasil memberikan kekebalan, proses mendasar yang diperlukan untuk menghasilkan kekebala